Abstract
A series of 3,7-dithiaPGE(1) analogues 3, 4, 11, 16 and 19 were identified as highly selective EP4-receptor agonists starting from the chemical modification of 7-thiaPGE(1) analogue 1. EP4-receptor selectivity and agonist activity were maximized in 3 and 4.
MeSH terms
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Alkenes / chemical synthesis*
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Alkenes / pharmacology*
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Animals
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Binding Sites
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CHO Cells / metabolism
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Cricetinae
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Cyclic AMP / agonists*
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Cyclopentanes / chemical synthesis*
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Cyclopentanes / pharmacology*
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Drug Design
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Humans
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Ligands
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Mice
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Receptors, Prostaglandin E / agonists*
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Receptors, Prostaglandin E, EP4 Subtype
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Sensitivity and Specificity
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Sulfur / chemistry*
Substances
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Alkenes
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Cyclopentanes
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Ligands
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PTGER4 protein, human
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Ptger4 protein, mouse
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Receptors, Prostaglandin E
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Receptors, Prostaglandin E, EP4 Subtype
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Sulfur
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Cyclic AMP